Abstract
The multifunctional smart hydrogels with temperature and NIR light triggering CIP release to inactivate bacteria have considerable practicability in the fields of drug delivery and wound dressing.
Highlights
Hydrogels often encounter relatively weak mechanical strength owing to the formation of microporous morphology during the gelation process,[18,19,20] which impedes its wide application in biomedical applications
It is worth noting that the diffraction peak at 2y of 251 of carbon nanotube (CNT) is obviously enhanced, which is caused by the increase in the degree of graphitization of CNT due to the transformation of amorphous carbon
In the infrared spectrum of CS, the absorption peak at 1591 cmÀ1 is the deformation vibration peak of –NH2, while this peak in the spectrum of QCGM disappears accompanied with two new peaks appearing at 1480 and 1643 cmÀ1, which are attributed to the C–H of methyl on GTMAC and the CQC stretching vibration peak on GMA, respectively
Summary
Hydrogels often encounter relatively weak mechanical strength owing to the formation of microporous morphology during the gelation process,[18,19,20] which impedes its wide application in biomedical applications. Recently by adopting carbon nanotube (CNT) as the additive to enhance the mechanical property of the materials and to endow the hydrogels with excellent NIR stimuli-responsive ability.[18,25,26,27] On the other hand, the rising incidence of infection by bacteria is another thorny issue in wound treatment.[28,29,30,31] wound dressings with inherent antibacterial ability represent better performance than broad-spectrum antibiotics in anti-wound infection.[28,32] Quaternized chitosan (QCS) exhibits more positive charges, which endow better antibacterial properties,[33,34] and exhibits better water solubility, hemostatic properties, and biocompatibility,[35,36] suggesting that it has broader application prospects.[27,37] developing multifunctional CNT-enhanced QCS based temperature-sensitive nanocomposite hydrogels in wound dressings is highly desirable. All of the above results demonstrated the great potential application of DEA–QCGM–CNT hydrogels as a biomechanically active multifunctional hydrogel wound dressing for wound-healing, which will provide a new approach to design bioactive wound dressing
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