Smart connected devices to objectively assess the adherence to eyedrops

Abstract

AbstractPurposeCompliance issues are often reported in ophthalmology for glaucoma which is one of the leading causes of blindness and visual disability and for dry eye syndrome (DES) requiring multiple frequent instillations. The smart electronic devices have emerged as one of the most reliable means of improving adherence to treatment, allowing objective quantification of the taken treatments. Aim: to report the pilot use in DES of two new electronic devices designed for the monitoring of adherence to eye drop medications.MethodsThe KaliDROP for eye drop bottles, and the KaliJAR for single‐dose‐units (SDU; Kali‐CARE, Santa Clara, CA, USA) were 3G wireless devices that recorded and transmitted in real respectively the number of instillations (when the bottle in pressed and reversed) and the number of SDU discarded after use. Both were tested by one of the author suffering from DES. The Kali Drop was tested during 28 consecutive days with an ABAK bottle of Thealose (Thea laboratories). The KaliJAR was tested during 47 consecutive days with SDU of Thealoz Duo Gel (Thea laboratories). In parallel, he noted on paper the date and time of each eye drop instillation. The agreement with the data recorded in the software was analyzed.ResultsOn the 354 instillations noted on paper, 352 (99.4%) were recorded by the KaliDROP device. Two instillations were not recorded, and one instillation was wrongly detected. On the 2200 SDUs introduced in the KaliJAR, 2136 (97.1%) were recorded. 64 SDUs (2.9%) were not recorded but none was wrongly detected. This percentage of false negative could be explained by the fact that 30–50 SDUs were inserted immediately one after the other. The number of undetected SDU would be virtually null if each SDU was discarded separately as normally recommended.ConclusionsThese two innovative simple‐to‐use devices could find strong applications in therapeutic education and clinical trials.