Abstract
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. Following the recent work of Mitchell and co-workers published in BMC Biology, we review how spatial and temporal control of signaling molecules in a matrix material regulates cellular responses for tissue-specific applications.See research article http://www.biomedcentral.com/1741-7007/8/57
Highlights
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior
Novel biomaterials should allow for the gradual endo genous remodeling of native tissue leading to the replace ment of implant material, manufactured to replace a missing biological structure, with fully functional extracellular matrix (ECM) and cells that existed at the implant site prior to damage
Sahni and colleagues investigated the natural binding affinity of fibroblast growth factor-2 (FGF-2), known as basic fibroblast growth factor, to fibrin, a fibrous protein formed during wound healing processes, and the ability of FGF-2 to influence proliferation of endothelial cells in vitro [7]
Summary
Important advances in the field of tissue engineering are arising from increased interest in novel biomaterial designs with bioactive components that directly influence cell behavior. The natural ECM supports organ and tissue structure and function, and regulates basic cellular functions like proliferation, growth, migration, differentiation, and survival. Biomaterial-induced vascularization The development of novel therapeutic approaches that stimulate the body to maintain the natural ability for new blood vessel formation is among challenges of tissue engi neering.
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