Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release.

Ortensia Parisi,Rocco Malivindi,Luca Scrivano,Francesco Puoci,Antonio Vassallo,Mariarosa Ruffo

doi:10.3390/ph11040092

Ortensia Parisi, Rocco Malivindi + Show 4 more

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https://doi.org/10.3390/ph11040092

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Abstract

The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release.

Highlights

Diclofenac (DC) is a phenylacetic acid derivative belonging to non-steroidal anti-inflammatory drugs (NSAIDs) and characterized by anti-inflammatory, analgesic and antipyretic activities [1,2,3]
The same batch binding studies were performed using standard solutions of phenylacetic acid (PAA), which is a structural analogue of diclofenac, in order to evaluate the selectivity properties of the imprinted polymer
The present study was focused on the development of a bandage incorporating Molecularly Imprinted Polymers for the topical administration of an anti-inflammatory drug such as diclofenac

Summary

Introduction

Diclofenac (DC) is a phenylacetic acid derivative belonging to non-steroidal anti-inflammatory drugs (NSAIDs) and characterized by anti-inflammatory, analgesic and antipyretic activities [1,2,3] This therapeutic agent is a non-selective inhibitor of the cyclooxygenase activity of prostaglandin H synthase [4] and it finds application in the treatment of inflammation and pain states related to several clinical conditions including arthritis, osteoarthritis, rheumatoid arthritis and acute gout, and muscle injuries. DC topical application using a bandage represents a less invasive option for the self-administration of this therapeutic agent In this context, the development of a “smart bandage” for DC topical administration able to release the drug in a controlled way can be a further advance allowing the reduction in dosing frequency and, dose related adverse effects. The present research study exploited Molecular Imprinting Technology for the preparation of Diclofenac Imprinted Polymers to be used as drug delivery system incorporated into the bandage

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