Abstract
Smallpox and Dracunculiasis: The Scientific Value of Infectious Diseases That Have Been Eradicated or Targeted for Eradication. Is Schistosomiasis Next?
Highlights
Chad, Ethiopia, Mali, and South Sudan [7,8]
The damage caused by chronic parasite egg deposition is significant and contributes to the high morbidity and mortality observed in schistosomiasis
The study of schistosomes, schistosomiasis pathogenesis, and immunological characterizations of the host response to parasite egg antigen are currently large areas of study that have been driven by use of schistosomes as a model organism to study stem cell biology, acute and chronic inflammation, liver and gut fibrosis, and T helper 2-type responses, among many others
Summary
Ethiopia, Mali, and South Sudan [7,8]. Despite being close to eradicating D. medinensis, we continue to use this parasite to understand endosymbiotic relationships in organisms. A second infectious pathogen that is targeted for eradication is Dracunculus medinensis, or guinea worm, the nematode parasite that causes drancunculiasis. Understanding why most filarial nematodes require Wolbachia, through comparative laboratory-based studies of Drancunculus, may inform endosymbiont-targeted efforts to eradicate other filarial parasites.
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