Abstract
To investigate the topological properties of the functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive impairment (SVCI) patients, resting-state fMRI and graph theory approaches were employed in 23 SVCI patients and 20 healthy controls. Functional connectivity between 90 brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs. Moreover, all of them were subjected to a battery of cognitive assessment, and the correlations between graph metrics and cognitive performance were further analyzed. Our results are as follows: functional brain networks of both SVCI patients and controls showed small-world attributes over a range of thresholds(0.15≤sparsity≤0.40). However, global topological organization of the functional brain networks in SVCI was significantly disrupted, as indicated by reduced global and local efficiency, clustering coefficients and increased characteristic path lengths relative to normal subjects. The decreased activity areas in SVCI predominantly targeted in the frontal-temporal lobes, while subcortical regions showed increased topological properties, which are suspected to compensate for the inefficiency of the functional network. We also demonstrated that altered brain network properties in SVCI are closely correlated with general cognitive and praxis dysfunction. The disruption of whole-brain topological organization of the functional connectome provides insight into the functional changes in the human brain in SVCI.
Highlights
Vascular cognitive impairment (VCI) includes all levels of cognitive loss from mild deficits in one or more cognitive domains to a broad dementia syndrome due to cerebral vessel disease [1]
The higher Activities of Daily Living Scale (ADL) scores in the Subcortical vascular cognitive impairment (SVCI) group further indicate the dysfunction in daily living compared to controls
We examined the small-world attributes of the resting state network in SVCI patients and matched normal controls
Summary
Vascular cognitive impairment (VCI) includes all levels of cognitive loss from mild deficits in one or more cognitive domains to a broad dementia syndrome due to cerebral vessel disease [1]. Subcortical vascular cognitive impairment (SVCI) is one of the most common subtypes of VCI due to subcortical cerebrovascular disease. It is characterized by extensive white matter hyperintensities (WMH). The primary clinical manifestation of SVCI is subcortical syndrome, the executive dysfunction, resulting from the interruption of prefrontal-subcortical loops[4]. SVCI is claimed to induce an increased risk of stroke, dementia, and death[5]. Because of its common occurrence, cost, and possible preventability, SVCI remains of great interest to clinicians and researchers
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