Abstract

Terahertz frequency domain spectroscopy (THzFDS) has been employed to study the result of variation of active pharmaceutical ingredients (API) on the effective refractive index of pharmaceutical tablets. A quasi-optical set-up with four off-axis parabolic mirrors was used to measure the effective refractive index of tablets in the frequency range of 500-750 GHz. It was observed that a small variation in API concentration can be detected using accurate measurements of the complex transmission coefficients. As a results, THz-FDS reveals to be an effective technique in monitoring the physical properties of pharmaceutical tablets.

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