Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease.

Linsey J F Peters,Donato Santovito,Christian Weber,Mathias Hohl,Emiel P C Van Der Vorst,Erik A L Biessen

doi:10.3389/fphys.2020.00793

Abstract

MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various biological fluids, such as serum, plasma, and urine. Over the last years, it has been shown that miRNAs are crucial in the development of several cardiovascular diseases (CVDs). This review discusses the (patho)physiological implications of miRNAs in CVD, ranging from cardiovascular risk factors (i.e., hypertension, diabetes, dyslipidemia), to atherosclerosis, myocardial infarction, and cardiac remodeling. Moreover, the intriguing possibility of their use as disease-specific diagnostic and prognostic biomarkers for human CVDs will be discussed in detail. Finally, as several approaches have been developed to alter miRNA expression and function (i.e., mimics, antagomirs, and target-site blockers), we will highlight the miRNAs with the most promising therapeutic potential that may represent suitable candidates for therapeutic intervention in future translational studies and ultimately in clinical trials. All in all, this review gives a comprehensive overview of the most relevant miRNAs in CVD and discusses their potential use as biomarkers and even therapeutic targets.

Highlights

MicroRNAs are short sequences (∼22 nucleotides) of endogenous non-coding RNA that emerged as a class of negative post-transcriptional regulators of gene expression
MicroRNAs in Cardiovascular Disease complex (RISC), a macromolecular complex where miRNAs loaded into the protein Argonaute-2 (AGO2) interact with the 3 untranslated region (3 UTR) of target RNAs
Extracellular miRNAs are detectable in human biological fluids such as serum, plasma, urine, and tears with peculiar changes in their expression associated with multiple diseases and regulated by treatments

Summary

Introduction

MicroRNAs (miRNAs) are short sequences (∼22 nucleotides) of endogenous non-coding RNA that emerged as a class of negative post-transcriptional regulators of gene expression. Starting from this early evidence, multiple studies have confirmed the expression of miRNAs in human cardiac and vascular tissues and provided strong evidence on the role of miRNAs in the development and progression of multiple cardiovascular diseases (CVDs).

Results

Conclusion