Year-end Sale % OFF 
Abstract
For a variety of reasons, bioassay experiments are frequently conducted with small sample sizes. However, the statistical literature offers little comparative information for small sample sizes among the analytical procedures most typically applied in vertebrate studies for chemical registration. A simulation study was performed to compare several traditional analytical procedures for estimating the median lethal dose (LD50). These estimation procedures include probit analysis with maximum likelihood estimation, logit analysis with maximum likelihood and minimum chi-square estimation methods, and analysis by a nonparametric moving average procedure. The simulation results indicate the conditions under which each analytical method appears most useful. Recommendations are tentatively made for minimally adequate designs for bioassay studies.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
