Abstract
Methods TNPB, Ped-ANAM, quality of life (PedsQL), and depression scales (CDI-S) were administered by psychology associates blinded to clinical status at two research visits. Differences in mean TNPB standardized scores, PedANAM throughput scores (raw Throughput=correct responses/minute), and clinical variables between visits were compared using paired Student t-tests. Multi-variable linear regression analysis was used to assess the influence of initial test performance, aPL/LAC status, disease duration, and cumulative prednisone dosing on composite TNPB or Ped-ANAM scores at a second visit.
Highlights
Neurocognitive impairment is a prevalent feature of SLE
Multi-variable linear regression analysis was used to assess the influence of initial test performance, aPL/LAC status, disease duration, and cumulative prednisone dosing on composite traditional neuropsychological battery (TNPB) or Ped-ANAM scores at a second visit
Twenty adolescents without active NPSLE were evaluated at two time points
Summary
Small practice effects on neurocognitive testing – markers of early cognitive impairment among adolescents with SLE?. Eyal Muscal1*, Debra L Canter, Douglas R Bloom, Barry L Myones, Stephen L Holliday, Robin L Brey. From 2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. Purpose Neurocognitive impairment is a prevalent feature of SLE. There is a paucity of data on the longitudinal assessment of cognitive performance of pediatric patients. There is no consensus on the timing of repeated neuropsychological evaluation in this population
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