Abstract

Specificity of leukocyte trafficking to intestinal mucosal tissues is largely mediated by MAdCAM- 1 α 4β 7 interaction. A series of small peptides was prepared to establish L-D-T-S-L as a recognition motif involved in the α 4 β 7 interaction. N-Terminus acylation of the L-D-T-S-L motif has led to low micromolar inhibitors of leukocyte adhesion. Leukocyte trafficking to intestinal mucosal tissues is largely mediated by a MAdCAM- 1 α 4β 7 interaction. A series of small peptides were prepared to establish L-D-T-S-L as a recognition motif involved. N-Terminus acylation of the L-D-T-S-L yielded micromolar inhibitors of leukocyte adhesion.

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