Small-molecule probe targeting viral PPxY L-domain inhibits filovirus and arenavirus egress.

Abstract

Abstract Viral matrix proteins containing a highly conserved PPxY Late (L) domain motif are critical for efficient viral budding of several emerging RNA viruses. The L domain motif functions by recruiting host cell proteins necessary for separation of virus particles from the cell surface during the budding process. The conserved nature of the PPxY motif and its importance for viral egress make it an attractive drug target with potential broad spectrum antiviral activity. Here we describe a PPxY inhibitor capable of reducing viral budding of four highly lethal, category A RNA viruses: Ebola, Marburg, Lassa, and Junín viruses.