Small Molecule Disruption of B. subtilis Biofilms by Targeting the Amyloid Matrix

Abstract

Small molecule inhibitors of amyloid aggregation have potential as treatment for a variety of conditions. In this issue of Chemistry & Biology, Romero and colleagues use amyloid-dependent B.subtilis biofilm formation to screen for amyloid inhibitors, identifying compounds that not only inhibit B.subtilis biofilm formation but also ones that disrupt preformed biofilms.