Abstract
Mucus glycoprotein secretion in the small intestine is an important component of intestinal defences [l]. Studies in animal models have shown that immune mediated events [2] will stimulate glycoprotein secretion in pulmonary or intestinal tissues. T lymphocytes have also been implicated in inducing goblet cell hyperplasia associated with intestinal helminth infections in rats [3]. Recent studies have shown that in patients with untreated coeliac disease, a condition in which there is strong evidence of alterations in mucosal T cell activation [4], intestinal glycoprotein synthesis and secretion is increased [5]. The aim of this study was to examine the effects of T cell activation on human small intestinal glycoprotein biosynthesis during short term culture in vitro.
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