Abstract
Parkinson's Disease Like stars in a brain that are “wider than the sky”, astrocyte-derived extracellular vesicles illuminate the intercellular space, landing on injured neurons to protect their mitochondria. This cover features work by Bianca Marchetti, Nunzio Iraci, and co-workers in article 2201203. Mouse brain regions involved in Parkinson's disease (PD, top): Striatum (blue), and ventral midbrain (green). Region-specific astrocytes release extracellular vesicles (EVs, carriers of signaling molecules, center). EVs protect injured neurons by preserving their mitochondrial functionality (bottom).
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