Abstract
Background and Aims : Maternal total cholesterol (TC) increases during pregnancy (maternal physiological hypercholesterolemia, MPH) assuring fetal development. However, a group of women develop supraphysiological hypercholesterolemia (MSPH), which associates with fetoplacental endothelial dysfunction, among others. Remarkably, MSPH effect on small extracellular vesicles (sEVs), which cold modulate endothelial function, has not been described. Aim: quantify sEVs from plasma of pregnant women with MPH and MSPH characterizing their effect on endothelial cells.
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