Abstract
Objective: To evaluate the efficacy and safety of small doses of propofol, droperidol, and metoclopramide for the prevention of postoperative nausea and vomiting (PONV) after thyroidectomy. Study design: Prospective, randomized, double-blinded study. Setting: University-affiliated teaching hospital. Methods: In a randomized, double-blinded study, 90 patients (75 females) received propofol 0.5 mg/kg, droperidol 20 μg/kg, or metoclopramide 0.2 mg/kg intravenously (n = 30 in each group) at the end of surgery. A standardized general anesthetic technique was used. Results: The incidence of PONV during the first 24 hours after anesthesia was recorded in 13%, 47%, and 50% of patients who had received propofol, droperidol, and metoclopramide, respectively ( P < 0.05; overall Fisher exact probability test). No clinically important adverse events were observed in any of the groups. Conclusion: Small dose (0.5 mg/kg) of propofol is more effective than droperidol or metoclopramide for the prevention of PONV after thyroidectomy. (Otolaryngol Head Neck Surg 2001;124:266-9.)
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