Small channels and large trials

Abstract

The culling of the first Dutch dairy herd, after the discovery of bovine spongiform encephalopathy in Friesland, brought home the potential for disaster. Is an epidemic of Creutzfeldt-Jakob disease (CJD) likely? Certainly, a new clinicopathlogical phenotype of CJD has been recognised in younger patients with a more protracted disease course. Striking early features are psychiatric disturbances, most often depression and sensory symptoms (Zeidler).