Abstract
Neuroendocrine carcinoma (NEC) of the endometrium is an uncommon tumor. Among the 80 cases of small cell neuroendocrine carcinoma of endometrium (SCNCE), that have been reported up to now. The tumors were either pure NEC or mixed with other histotypes , most commonly endometrioid carcinoma. We report a case of primary small cell neuroendocrine carcinoma of endometrium. The clinical symptoms related to SCNCE are similar to those of endometrial cancer. Immunohistochemical studies with neuroendocrine markers are necessary to make a definitive diagnosis and differentiate it from other small cell carcinomas. The only known prognostic factor is the stage of the disease. Although SCNCE is a rare tumor, it is a tumor that must be kept in mind as it is high grade and has a poor prognosis in this context. Multicentre studies are needed to identify specific prognostic factors and develop different treatment options.
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