Abstract
The occurrence of cervical cancer during pregnancy is extremely rare, particularly small cell carcinoma. Small cell cervical carcinoma (SCCC) is a neuroendocrine tumor with a poor prognosis. This study presents the case of an 18-year-old female with stage IB2 SCCC complicated by pregnancy, who was treated with chemotherapy and radiotherapy. The patient was diagnosed shortly after giving birth, and is the youngest female case to be reported in the world. The patient was treated with cisplatin and etoposide chemotherapy and radiotherapy. Complete remission was achieved following neoadjuvant chemotherapy and radiotherapy, and the patient remains in clinical remission eight months following treatment. Cytological screening, colposcopy and if necessary, biopsy, and selective conization at 14–20 weeks should be considered in the patient evaluation.
Highlights
Small cell cervical carcinoma (SCCC) is a neuroendocrine tumor with great aggravation
The diagnosis of SCCC was aided by immunohistochemical staining for common neuroendocrine markers, including Syn, chromogranin A (CgA), neuron‐specific enolase (NSE) and CD56
SCCC may rapidly metastasize to the lungs, liver, brain, bones and pancreas
Summary
Small cell cervical carcinoma (SCCC) is a neuroendocrine tumor with great aggravation. Chemoradiation has been shown to improve survival in non‐small cell carcinoma of cervix, the optimal initial therapeutic approach has not been identified in SCCC [2]. Standard chemotherapy regimens, such as cisplatin and etoposide, are administered according to the management of small cell lung cancer. After the fourth cycle of NACT, MRI revealed a 90% decrease in tumor size when compared with previous MRI scans of the cervical mass and an 80% decrease in size of the lymph nodes (Fig. 2). Three weeks after completing NACT, the patient received 3D intensity‐modulated radiation therapy with a total dose of 44 Gy administered to the pelvis and 54 Gy to the pelvic lymph nodes. On February 20, 2014, the patient was disease‐free without signs of recurrence
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