Abstract

Small size gold nanorods (diameter < 6 nm) are limited to use as photoacoustic imaging agents due to its poor performance. To address this limitation, local surface plasmon resonance (LSPR) coupling effect produced by the aggregation of Au nanoparticles is a commonly used strategy to enhance its performance. Herein, a small Au NRs aggregation assembled by MnO2 nanosheet (Au NRs-MnO2) was explored. As expected, the Au NRs-MnO2 exhibited obviously enhanced NIR absorption compared with small Au NRs and the PA intensity of the Au NRs-MnO2 dispersed in water was 2.7 times that of Au NRs. More importantly, the Au NRs-MnO2 exhibited excellent tumor imaging in vivo. Therefore, the obtained Au NRs-MnO2 aggregation will provide an effective strategy for small size Au NRs to enhance PA imaging.

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