Abstract
Introduction: Hepatocellular carcinoma (HCC) is the most frequent primary liver tumor. The transforming growth factor-β (TGF-β) signaling pathway plays a critical role in cancer progression. Smad7, a TGF-β target gene, acts as physiological feedback inhibitor of TGF-β and has been found tumorigenic in several tumors. Knowledge about the role of Smad7 in HCC is limited so far. This study investigated the potential effects of Smad7 in a DEN induced HCC mouse model.
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