Abstract
Currently, there is no biomarker or effective treatment for Spinal and bulbar muscular atrophy (SBMA) patients. A recent clinical trial using Leuprorelin showed a modest effect on dysphagia, and an increased survival rate in SBMA. The aim of our study was to find an early marker of treatment efficiancy using Leuprorelin in 40 Korean SBMA patients. The Videofluoroscopic swallowing study (VFSS) and amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) were performed at baseline and after androgen suppression therapy for one year in these patients.
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