Abstract
Background: IL-1β is a multifunctional pro-inflammatory cytokine associated with diverse inflammatory disorders. IL-1β release requires two consecutive danger signals. LPS is a prototypical first signal inducing pro-IL-1β synthesis, whereas extracellular ATP is a typical second signal triggering inflammasome activation, proteolytic cleavage of pro-IL-1β by activated caspase-1, and release of mature IL-1β. Secretory leukocyte protease inhibitor (SLPI), in addition to its well-known function as major anti-protease of the lung, possesses potent anti-microbial and anti-inflammatory properties. Here, we test the hypothesis that IL-1β release is inhibited by SLPI.
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