SLOX-1: A Molecule for Evaluating the Prognosis of Recurrent Ischemic Stroke.

Yangmin Zheng,Yuyou Huang,Ziping Han,Fangfang Zhao,Rongliang Wang,Zhen Tao,Yumei Liu,Fangfang Li,Lingzhi Li,Yumin Luo,Haiping Zhao,Junfen Fan,Feng Yan,Pingping Wang,Xi-Ze Jia

doi:10.1155/2021/6718184

Yangmin Zheng, Yuyou Huang + Show 13 more

Open Access

https://doi.org/10.1155/2021/6718184

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Abstract

Several clinical parameters and biomarkers have been proposed as prognostic markers for stroke. However, it has not been clarified whether the risk factors affecting the prognosis of patients with recurrent and first-ever stroke are similar. In this study, we aimed to explore the relationship between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and the prediction of the functional outcome in patients with recurrent and first-ever stroke. A total of 266 patients with recurrent and first-ever stroke, who underwent follow-up for 3 months, were included in this study. Plasma samples were collected within 24 h after onset. The results showed that biomarkers for the prognosis of patients with recurrent stroke were different from that of those with first-ever stroke. sLOX-1 levels were correlated with modified Rankin Scale scores of patients with recurrent stroke alone (r = 0.3232, p = 0.001). sLOX-1 levels were also associated with an increased risk of unfavorable outcomes in patients with recurrent stroke with an adjusted odds ratio of 1.489 (95% confidence interval, 1.204–1.842, p < 0.0001). Combining the risk factors showed greater accuracy for prognosis, yielding a sensitivity of 93.2% and a specificity of 75%, with an area under the curve of 0.916, evaluated by the receiver operating characteristic curve. These findings suggest that the diagnosis and prognosis are different between patients with recurrent stroke and those with first-ever stroke, and sLOX-1 level is an independent prognostic marker in patients with recurrent stroke.

Highlights

Stroke is a type of cerebrovascular disorder with high morbidity, disability, mortality, and recurrence rate
It is important to explore the risk factors affecting the prognosis of patients with recurrent ischemic stroke and to assess the condition and short-term prognosis of patients with recurrent stroke to improve their quality of life [4]
No linear correlation was found between soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) levels and mRS score at 3 months in all patients with acute ischemic stroke (AIS) or with first-ever stroke

Summary

Introduction

Stroke is a type of cerebrovascular disorder with high morbidity, disability, mortality, and recurrence rate. Patients with previous stroke have a significantly increased risk of recurrence, and their severe disability and mortality rates are significantly higher [3]. It has not been clarified whether the risk factors of recurrent and first-ever stroke are completely similar, and there are few studies on the severity and short-term prognosis of recurrent ischemic stroke. It is important to explore the risk factors affecting the prognosis of patients with recurrent ischemic stroke and to assess the condition and short-term prognosis of patients with recurrent stroke to improve their quality of life [4]. After screening patients with a history of stroke during clinical diagnosis and treatment, the direction of future research is to determine whether individualized treatment can be provided

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