Abstract
We have previously reported (Can. J. Physiol. Pharmacol. 1969. 47, 815–826) that sustained oscillations of blood pressure, similar to Mayer waves, can be produced by the drug picrotoxin in anesthetized cats. We have investigated further the properties of these oscillations by recording the electrical activity of sympathetic preganglionic, somatic motor, and phrenic nerves. We found that the sympathetic preganglionic and somatic motor nerves show a periodic increase of electrical activity in synchrony with the oscillations of blood pressure. The phrenic nerve shows changes in repetition rate and duration of its bursting activity, which are synchronous with the blood pressure waves (i.e. phrenic bursts are more frequent and longer lasting on the ascending than on the descending limb of the blood pressure waves). The synchronous oscillation of these three output systems is not due to proprioceptive feedback because it is present when the animals are paralyzed, ventilated artificially, and even when the blood pressure is prevented from oscillating by ganglionic block. We conclude that the observed rhythmic pattern of neural activity is generated in the central nervous system.
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