Slow cortical DC-potential responses to sweet and bitter tastes in humans

Abstract

Processing of hedonic stimulus quality is assumed to be accompanied by a tuning of cortical arousal and excitability. In this pilot study in 11 healthy humans scalp-recorded DC potentials were assessed during application of a sweet (sucrose) and bitter (quinine hydrochloride) taste, i.e., primary reinforcers of positive and negative quality. Muscular, ocular, and skin potential activity were controlled. Application of sucrose induced a widespread positive DC-potential shift with an amplitude of 40–50 μV and persisting for more than 120-s post-stimulus onset. Following administration of quinine hydrochloride, this positive shift was reduced, most distinctly between 48- and 88-s post-stimulus onset. The reduction appeared to be most consistent at anterior midline recording sites (Fz, Cz). It is assumed that the higher DC-potential positivity during sweetness than during bitterness points to a differential tuning of cortical excitability by a widespread decrease in depolarization of apical dendrites.