Slow and fast axonal transport of acetylcholinesterase molecular forms in polyarthritic rats

Abstract

Acetylcholinesterase (AChE) activity and its distribution among different molecular forms were studied in the sciatic nerve of normal and polyarthritic rats. Axonal transport of each form was investigated on the basis of its accumulation on both sides of a transection. Although an increase in total AChE activity could be detected in the sciatic nerves of polyarthritic animals, both anterograde and retrograde axonal transport of all the molecular forms investigated were similar in normal and polyarthritic rats. This suggest that neither slow nor fast axonal transport is impaired in polyarthritic rats. Hence, the neurophysiological modification observed at the spinal, thalamic and cortical levels of the CNS are presumably not a consequence of peripheral axonal disability.