Slope of the power spectral density flattens at low frequencies (200Hz) in human electroencephalogram.

Abstract

The power spectral density (PSD) of the brain signals is characterized by two distinct features: oscillations, which are represented as distinct "bumps," and broadband aperiodic activity, that reduces in power with increasing frequency and is characterized by the slope of the power falloff. Recent studies have shown a change in the slope of the aperiodic activity with healthy aging and mental disorders. However, these studies analyzed slopes over a limited frequency range (<100Hz). To test whether the PSD slope is affected over a wider frequency range with aging and mental disorder, we analyzed the slope till 800Hz in electroencephalogram data recorded from elderly subjects (>49years) who were healthy (n = 217) or had mild cognitive impairment (MCI; n = 11) or Alzheimer's Disease (AD; n = 5). Although the slope reduced up to ~ 150Hz with healthy aging (as shown previously), surprisingly, at higher frequencies (>200Hz), it increased with age. These results were observed in all electrodes, for both eyes open and eyes closed conditions, and for different reference schemes. However, slopes were not significantly different in MCI/AD subjects compared with healthy controls. Overall, our results constrain the biophysical mechanisms that are reflected in the PSD slopes in healthy and pathological aging.