SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and pre-replicative complex assembly

Ilona Faustova,Mart Loog

doi:10.1016/j.molcel.2021.04.016

SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and pre-replicative complex assembly

Ilona Faustova, Mart Loog

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https://doi.org/10.1016/j.molcel.2021.04.016

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Journal: Molecular Cell	Publication Date: May 1, 2021
Citations: 4	License type: publisher-specific-oa

Affiliation: University of Tartu

#Short Linear Motifs #Pre-replicative Complex Assembly + Show 8 more

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Abstract

Hossain etal. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interaction and its regulation by CDKs.

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