Abstract
It is the general consensus that a sliding hiatus hernia (HH) is important in the pathogenesis of gastroesophageal reflux (GER) disease. However, the mechanism by which HH contributes to the pathogenesis of GER disease has been debated for many decades. 1 Tack J. et al. Gastroenterology. 2018; 154: 277-288 Abstract Full Text Full Text PDF PubMed Scopus (83) Google Scholar GER implies the flow of stomach contents into the esophagus; it should follow the physical principles of pressure gradient and sphincter that facilitate and restrict flow, respectively. High-resolution manometry (HRM) impedance recordings allow the accurate measurement of the intraluminal pressure and flow at closely spaced intervals. We studied whether respiration-induced pressure changes in the esophagus, lower esophageal sphincter (LES), HH, crural diaphragm (CD), and stomach are conducive to GER in HH patients.
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