Abstract
Background In non-contrast coronary MRA, the non-selective T2Prep 1-2 has been widely used for contrast enhancement between the coronary blood-pool and the myocardium. This non-selective pre-pulse affects the magnetization both inside and outside the field-of-view, resulting in a reduced steady-state magnetization of the inflowing blood, and consequently a penalty in SNR. We hypothesize that a slice-selective T2Prep would leave the magnetization of blood outside the imaged volume unaffected, and thereby minimize SNR penalty for inflowing blood. The purpose of this work was to implement a slice-selective T2Prep coronary MRA sequence and to assess the SNR gain quantitatively.
Highlights
In non-contrast coronary MRA, the non-selective T2Prep[1,2] has been widely used for contrast enhancement between the coronary blood-pool and the myocardium[3,4,5]
Implementation the selective T2Prep was implemented by replacing the non-selective 90° RF pulses with slice-selective versions plus flow-compensating gradients, and an additional time gap between the T2Prep and other pre-pulses to allow for inflow of a larger volume of spins with equilibrium magnetization (Figure1)
When compared to the non-selective T2Prep, vessel sharpness improved significantly using the proposed implementation (54.1 ±2.4% vs. 48.5±2.4%, p
Summary
In non-contrast coronary MRA, the non-selective T2Prep[1,2] has been widely used for contrast enhancement between the coronary blood-pool and the myocardium[3,4,5]. This non-selective pre-pulse affects the magnetization both inside and outside the field-of-view, resulting in a reduced steady-state magnetization of the inflowing blood, and a penalty in SNR. We hypothesize that a slice-selective T2Prep would leave the magnetization of blood outside the imaged volume unaffected, and thereby minimize SNR penalty for inflowing blood. The purpose of this work was to implement a slice-selective T2Prep coronary MRA sequence and to assess the SNR gain quantitatively
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