Abstract
Fenfluramine produced a dose-dependent, biphasic effect on sleep-waking patterns in cats. At low doses (0.4 mg/kg) fenfluramine elicited an increase in total waking time and a marked reduction in REM sleep, similar to that seen after administration of amphetamine, without affecting SWS. At anorectic doses (5.0 mg/kg) fenfluramine almost completely suppressed REM sleep, reduced waking time and increased SWS, an effect similar to that seen after administration of 5-HTP, the precursor of serotonin. The fenfluramine-induced increase in SWS was facilitated by 5-HTP and blocked by LSD, a serotonin antagonist. Serotonin was significantly reduced in the neocortex, pyriform lobe, cerebellum and hindbrain at the time of the drug's peak effect on SWS suggesting that the fenfluramine-induced increase in SWS is mediated via serotonin dependent mechanisms.
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