Abstract
Sleep-disordered breathing occurs frequently in neuromuscular diseases and chest wall disorders as a result of the effects of normal sleep on ventilation and additional challenges imposed by specific disorders. Patterns of sleep-disordered breathing include sleep-related hypoventilation and hypoxemia as well as sleep apnea. Sleep-related hypoventilation precedes diurnal respiratory failure and clinical presentation is often nonspecific. Polysomnography may be useful to identify patterns and severity of sleep-disordered breathing and to titrate therapy. Noninvasive positive pressure ventilation is considered first line therapy in patients with progressive restrictive thoracic disorders and respiratory insufficiency.
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