Sleep quality does not mediate the negative effects of chronodisruption on body composition and metabolic syndrome in healthcare workers in Ecuador

Tannia Valeria Carpio Arias,Diana Carolina Mogrovejo Arias,Tomas Marcelo Nicolalde Cifuentes,Estephany Carolina Tapia Veloz,Chris I De Zeeuw,María Fernanda Vinueza Veloz

doi:10.1016/j.dsx.2021.01.017

Abstract

Background and aimsThe objective of the present work was to determine to what extent sleep quality may mediate the association between chronodisruption (CD) and metabolic syndrome (MS), and between CD and body composition (BC). MethodologyCross-sectional study which included 300 adult health workers, 150 of whom were night shift workers and thereby exposed to CD. Diagnosis of MS was made based on Adult Treatment Panel III criteria. Sleep quality was measured using the Pittsburgh Sleep Quality Index. Body mass index (BMI), fat mass percentage, and visceral fat percentage were measured as indicators of body composition (BC). Data were analyzed using logistic, linear regression and structural equation models. ResultsThe odds of health workers exposed to CD to suffer MS was 22.13 (IC95 8.68–66.07) when the model was adjusted for age, gender, physical activity and energy consumption. CD was also significantly associated with an increase in fat mass and visceral fat percentages, but not to BMI. Surprisingly, there was not enough evidence supporting the hypothesis that sleep quality contributes to the association between CD and MS or between CD and BC. ConclusionsSleep quality does not mediate the negative effects of CD on MS nor on BC.

Highlights

Chronodisruption (CD), which concerns a significant disturbance of the circadian organization of physiology, metabolism and behavior, can lead to disturbances in metabolic activity, potentially generating a negative vicious circle [1,2]
The sample included 300 adult men and women (65% and 35%, respectively), half of whom were exposed to CD, because they were night shift workers (n 1⁄4 150 vs. n 1⁄4 150)
Our findings suggest that CD increases the odds of metabolic syndrome (MS) and changes body composition (BC) in that, it increases the percentage of both fat mass and visceral fat

Summary

Introduction

Chronodisruption (CD), which concerns a significant disturbance of the circadian organization of physiology, metabolism and behavior, can lead to disturbances in metabolic activity, potentially generating a negative vicious circle [1,2]. Show increased odds of smoking and consuming higher amounts of caffeine [2,6,7], suffer from body weight increase [15], often are faced with severe sleep disturbances [10,11] These findings raise the possibility that hampered quality of sleep is one of the main factors contributing to the link between CD and MS. To investigate this hypothesis we set out to investigate whether sleep quality mediates the association between CD and MS and between CD and BC in a group of night shift workers and a group of regular day workers for control.

Objectives

Results

Conclusion