Abstract
We performed 10-hour polysomnographic recordings in 15 neurologically normal and clinically stable 33- to 34-week postmenstrual age (PMA) neonates, 10 of whom had been treated >3 days with once-per-day oral caffeine citrate (5 mg/kg) given at ~2 PM. We analyzed (a) the usual sleep-wake variables, including wakefulness, active sleep, quiet sleep, and indeterminate sleep expressed as the number of episodes, duration, and percentage of total sleep time; (b) the duration and order of variable modifications during transitions between the main active sleep and quiet sleep states; and (c) the characteristics of morning data (before caffeine) compared with evening data (after caffeine). We found no significant differences between the controls and the infants receiving maintenance caffeine. (J Pediatr 2002;140:766-71)
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