Sleep, learning, and memory in human research using noninvasive neuroimaging techniques

Abstract

An accumulating body of evidence indicates that sleep is beneficial for learning and memory. Task performance improves significantly after a period that includes sleep, whereas a lack of sleep nullifies or impairs such improvements. Our current knowledge about sleep’s role in learning and memory has been obtained based on studies that were conducted in both animal models and human subjects. Nevertheless, how sleep promotes learning and memory in humans is not fully understood. In this review, we overview our current understating of how sleep may contribute to learning and memory, covering different roles of non-rapid eye movement and rapid eye movement sleep. We then discuss cutting-edge advanced techniques that are currently available, including simultaneous functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) and simultaneous functional magnetic resonance spectroscopy (fMRS) and EEG measurements, and evaluate how these may contribute to advance the understanding of the role of sleep in human cognition. We also highlight the current limitations and challenges using these methods and discuss ways that may allow us to overcome these limitations.