Abstract
Sleep is an Auto-Regulatory Global Phenomenon
Highlights
Behavioral observations, and electrophysiological signals produced by the brain regions below and above the transection of the brain in experimental studies, showed that almost every part of the brain has the inherent ability to show sleep-wake oscillation (Villablanca, 1965)
More recently a novel mechanism for sleep-wake control, based on gamma band activity, was described. It supports the global nature of sleep-wake oscillation that is orchestrated by brainstem–thalamic mechanism, and questions the undue importance given to the hypothalamus for the regulation of sleep-wakefulness (Urbano et al, 2012)
Even the same transmitter under different experimental conditions can produce opposing responses (Kumar, 2005; Kumar et al, 2006, 2007). These findings question the very idea of assigning a sleep regulatory role to any one particular brain region
Summary
Behavioral observations, and electrophysiological signals produced by the brain regions below and above the transection of the brain in experimental studies, showed that almost every part of the brain has the inherent ability to show sleep-wake oscillation (Villablanca, 1965). This may be considered as some of the earliest evidence in support of global nature of sleep regulation and auto-regulatory capacity of every brain region for sleep genesis, even though these eminent scientists who conducted the transection studies never made such a claim. Even the common clinical observations where sleep re-emerges after strokes do support the global auto-regulatory nature of sleep.
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