Sleep influences neural representations of true and false memories: An event-related potential study

Abstract

Episodic memory is reconstructive and is thus prone to false memory formation. Although false memories are proposed to develop via associative processes, the nature of their neural representations, and the effect of sleep on false memory processing is currently unclear. The present research employed the Deese-Roediger-McDermott (DRM) paradigm and a daytime nap to determine whether semantic false memories and true memories could be differentiated using event-related potentials (ERPs). We also sought to illuminate the role of sleep in memory formation and learning. Healthy participants (N = 34, 28F, mean age = 23.23, range = 18–33) completed the learning phase of the DRM task followed by an immediate and a delayed recognition phase. The two recognition phases were separated by either a 2hr daytime nap or an equivalent wake period. Linear mixed modelling of effects at delayed recognition revealed larger LPC amplitudes for true memories in contrast to false memories for those in the wake group, and larger P300 amplitudes for false compared to true memories across sleep and wake groups. Larger LPC amplitudes for true memories were associated with enhanced true memory recognition following sleep, whilst larger P300 amplitudes were associated with similar true and false memory recognition rates. These findings are argued to reflect sleep’s ability to promote memory generalisation associated with pattern completion, whilst also enhancing true memory recognition when memory traces have a strong episodic basis (linked to pattern separation). The present research suggests that true and false memories have differing neural profiles and are reflective of adaptive memory processes.