Abstract
Here we report the first and most robust evidence about how sleep habits are associated with regional brain grey matter volumes and school grade average in early adolescence. Shorter time in bed during weekdays, and later weekend sleeping hours correlate with smaller brain grey matter volumes in frontal, anterior cingulate, and precuneus cortex regions. Poor school grade average associates with later weekend bedtime and smaller grey matter volumes in medial brain regions. The medial prefrontal - anterior cingulate cortex appears most tightly related to the adolescents’ variations in sleep habits, as its volume correlates inversely with both weekend bedtime and wake up time, and also with poor school performance. These findings suggest that sleep habits, notably during the weekends, have an alarming link with both the structure of the adolescent brain and school performance, and thus highlight the need for informed interventions.
Highlights
Medicine and Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College, 16 De Crespigny Park, London SE5 8AF, United Kingdom. 8Departments of Psychiatry and Psychology, 6436 UHC, University of Vermont. 1 South Prospect Street, Burlington, VT 05401, USA. 9APHP, Adolescent Psychopathology and Medicine department, Maison de Solenn, Cochin Hospital, 97 Bd de Port Royal, 75014 Paris, France. 10CENIR at ICM institute, www.nature.com/scientificreports/
Later weekend bedtimes were associated with poorer school grade average, and both of these were further associated with small GMV in the medial prefrontal cortex (PFC) region
Shorter weekday sleep and later weekend sleep habits associated with smaller brain regional GMV among 14-year-old community adolescents
Summary
It showed that sleep duration during weekdays correlated with GMVs in bilateral hippocampal and right dorsolateral prefrontal cortex (DLPFC)[13]. Among adolescents, later weekend bedtimes correlated with smaller brain GMVs in frontal, anterior cingulate, and precuneus cortex regions. Shorter weekday time in bed correlated with smaller GMVs in frontal regions. These results highlight especially the possible adverse link of late timing of weekend sleep with the maturing adolescent brain and school performance
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