SLEEP DURATION AND TIMING ARE NOT ASSOCIATED WITH ANTIMULLERIAN HORMONE LEVELS

Abstract

Many women who consider future family building seek advice regarding modifiable behaviors and reproductive health. To determine if sleep duration and timing are associated with AMH levels in a reproductive aged, Midwestern cohort of women. Cross sectional study. 200 women aged 18-44 years with regular menstrual cycles were enrolled into the LORE study, a cross-sectional cohort study designed to investigate associations between lifestyle factors and ovarian reserve. Women who were currently pregnant or who had history of major chronic illness, infertility or ovarian surgery were excluded. Fasting blood was drawn and stored at -80 degrees for batched analysis. Samples were run on the Roche Elecsys analyzer for AMH levels. Participants also completed a survey that included questions regarding typical bedtime and wake time on work and non-work days. Sleep measures included duration of sleep, midsleep point (defined as the midpoint time between bedtime and wake time, also known as chronotype), and social jetlag (the difference in midsleep point on workdays and non-work days of >1 hour). Standard bivariate statistics were run to determine associations between sleep duration, timing of sleep and AMH levels. SPSS v.25 was used for analysis. Participants had an average age of 30.9 ± 6.7 years and an average body mass index of 28.3 ±7.1. The majority of the participants were white (n=136, 68%); thirty percent were black (n=60). The average AMH level was 2.9 ±2.0 ng/mL. Average duration of sleep was 7.2 hours (Range 4.0 to 11.0 hours). Average mid sleep point on work nights was 2:51 AM and on non-work nights was 3:54 AM. Average social jet lag was 1:31 hours (range 0 to 14:30 hours). None of these measures were associated with AMH. This data suggests that for healthy, reproductive aged women in the Midwest, modifying sleep duration and timing is unlikely to improve or adversely affect AMH.