Abstract
BackgroundSeveral studies have reported a significant association between sleep disturbance and inflammatory bowel disease (IBD). The aim of the present study is to compare the clinical characteristics and the health-related quality of life (HR-QOL) of Japanese IBD patients with or without sleep disturbances, and to investigate the risk factors for disease flare in these patients.MethodsIBD patients were asked to complete a self-administered questionnaire including the Pittsburg sleep quality index and the 8-item short-form health survey. The information about disease flare within 1 year from enrollment in the study was analyzed with a multiple logistic regression model to identify risk factors for IBD flare-ups.ResultsThe prevalence of sleep disturbances was 44.1 % (60 out of 136 IBD patients). Use of sleep medications was significantly higher in IBD patients with sleep disturbances whereas use of immuno modulators was significantly higher in IBD patients without sleep disturbances. The scores from all HR-QOL domains were significantly lower in patients with sleep disturbances than in patients without sleep disturbances. Fifty-one patients (37.5 %) had disease flare within 1 year from enrollment in the study and sleep disturbances were identified as a significant risk factor for disease flare (OR 3.09, 95 % CI 1.47–6.43).ConclusionsOur results indicate that sleep disturbances are common in Japanese IBD patients and are associated with poorer HR-QOL. Since the presence of sleep disturbances is a significant risk factor for IBD flare-ups, we encourage physicians to perform a careful examination of sleep disturbances in IBD patients.
Highlights
Several studies have reported a significant association between sleep disturbance and inflammatory bowel disease (IBD)
The aim of the present study was to compare the clinical characteristics and health-related quality of life (QOL) (HR-QOL) of IBD patients according to the presence or absence of sleep disturbances, and to investigate the risk factors for disease flare within 1 year from enrollment in the study
Use of sleep medications was significantly higher in IBD patients with sleep disturbances whereas use of immuno modulators was significantly higher in IBD patients without sleep disturbances
Summary
Several studies have reported a significant association between sleep disturbance and inflammatory bowel disease (IBD). Significant associations between sleep disturbances and gastroesophageal reflux disease (Fujiwara et al 2012), Uemura et al SpringerPlus (2016) 5:1792 functional dyspepsia (Lacy et al 2011), irritable bowel syndrome (Ranjbaran et al 2007a; Nojkov et al 2010), and IBD (Ranjbaran et al 2007a; Graff et al 2011; Ali et al 2013; Gingold-Belfer et al 2014; Ananthakrishnan et al 2013, 2014) have been reported. The prevalence of sleep disturbances in Japanese IBD patients and the association between sleep disturbances and disease flare is unknown
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
