Abstract
Adipokines are a growing group of peptide or protein hormones that play important roles in whole body metabolism and metabolic diseases. Sleep is an integral component of energy metabolism, and sleep disturbance has been implicated in a wide range of metabolic disorders. Accumulating evidence suggests that adipokines may play a role in mediating the close association between sleep disorders and systemic metabolic derangements. In this review, we briefly summarize a group of selected adipokines and their identified function in metabolism. Moreover, we provide a balanced overview of these adipokines and their roles in sleep physiology and sleep disorders from recent human and animal studies. These studies collectively demonstrate that the functions of adipokine in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that likely contribute to systemic metabolic derangements.
Highlights
Adipokines are secreted peptides and proteins produced by adipose tissue
Studies on adipokines have revealed the importance of adipose tissue as a metabolically active tissue/organ in mediating crosstalk among different tissues and organs [2]
We aim to provide a balanced discussion of emerging evidence from both human and animal studies on the role of adipokines in sleep physiology and sleep disorders. These studies collectively demonstrate that the functions of adipokines in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that are important in systemic metabolic derangements
Summary
Adipokines ( known as adipocytokines) are secreted peptides and proteins produced by adipose tissue. Sleep disturbance has been implicated in a wide range of metabolic disorders contributing to significant morbidity and mortality [3] This has been studied extensively in epidemiological studies in the context of the modern epidemic of metabolic syndrome, a cluster of medical conditions that include central obesity, systemic hypertension, insulin resistance, and dyslipidemia. We aim to provide a balanced discussion of emerging evidence from both human and animal studies on the role of adipokines in sleep physiology and sleep disorders. These studies collectively demonstrate that the functions of adipokines in sleep physiology and disorders could be largely twofold: (1) adipokines have multifaceted roles in sleep physiology and sleep disorders, and (2) sleep disturbance can in turn affect adipokine functions that are important in systemic metabolic derangements
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