Abstract
Neuroscience Dementia affects nearly 36 million people worldwide, a number that is expected to double within the next two decades. Sleep disruption is thought to underlie some aspects of cognitive decline and neurodegeneration. Kaneshwaran et al. assessed sleep disruption in two cohort studies of older persons—the Rush Memory and Aging Project and the Religious Orders Study. In the subjects, greater sleep fragmentation was associated with higher neocortical expression of genes characteristic of microglial aging and activation. This valuable human data may provide therapeutic pointers for the treatment of neurodegenerative disorders. Sci. Adv. 10.1126/sciadv.aax7331 (2019).
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