Sleep disorders in patients with myastenia gravis

Abstract

This review analyzes publications that present data on sleep disorders in patients with myasthenia gravis (MG). The analysis is based on domestic and foreign publications that are freely available over the past 30 years. Sleep disorders, the most significant of which are sleep-related respiratory disorders, are one of the factors that cause quality of life decreasing and mortality in patients with neuromuscular diseases. The issues of prevalence of breathing disorders during sleep, relationship of these disorders with clinical and immunological characteristics of disease, demographic indicators are studied. The influence of sleep breathing disorders on quality of life and affective sphere of patients is discussed. Most studies prove that sleep-related respiratory disorders occur in patients with MG significantly more often than in general population. Some studies show a high prevalence of poor sleep quality, excessive daytime sleepiness in patients with MG, while others do not report such associations. However, studies that failed to establish an association with MG and sleep disturbances were of small sample sizes. Thus, given the inconclusive evidence and limited literature, further study of sleep disorders in patients with MG is needed. The topic is relevant and requires further development.