Sleep Disorders in Patients with Congenital Generalized Lipodystrophy

Abstract

Background and Aims: Sleep disorders are often associated with the several metabolic complications. Congenital generalized lipodystrophy (CGL) is associated with severe insulin resistance, diabetes, dyslipidemia and hepatic steatosis in non-obese individuals, but there are no data evaluating the presence of sleep disorders in this condition. The aim of this study was to describe the characteristics of sleep pattern in individuals with CGL and evaluate the presence of sleep disorders in these patients. Materials and Methods: A cross-sectional study with 8 patients with CGL. It was performed a polysomnography following the guidelines of the American Academy of Sleep Medicine. Results: There were 2 male and 6 female patients. The median age of these patients is 16,5 years old, ranging from 7 to 33 years old. All patients have hypertriglyceridemia and 6/8 had diabetes. Hepatic steatosis was observed in 4/8 cases (50%) and systemic arterial hypertension in 1/8 case (12,5%). Snore was observed in 7/8 (87,5%) of the sample. The diagnosis of obstructive sleep apnea syndrome was observed in 6/8 (75%) of the individuals, rapid eye movement sleep (REM) behavior disorder in 4/8 (50%), changes in sleep efficiency in 4/8 (50%), fragmented sleep in 8/8 (100%) and periodic leg movements in 7/8 (87,5%). There were no significant cardiovascular abnormalities in this study. Conclusion: The patients with CGL evaluated showed a high frequency of sleep disorders. These findings in a young no-obese population, but with severe metabolic abnormalities, suggest its negative impact in sleep quality of these patients, increasing the cardiovascular risk in this population. Disclosure V.O. Fernandes: None. C.P. Silva: None. A.D.R. Montenegro: None. C.M.M. Ponte: None. L.A.A. Batista: None. T.F. Pinto: None. I.T. Vasconcelos: None. L.A.S. Karbage: None. P.M. Fernandes: None. C.B. D'Alva: None. P.F.C. Bruin: None. R.M. Montenegro: None.