Abstract
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative disease. Here, we describe clinical features of sleep disorders in AD and the relation between sleep disorders and both cognitive impairment and poor prognosis of the disease. There are difficulties of the diagnosis of sleep disorders based on sleep questionnaires, polysomnography or actigraphy in the AD patients. Typical disturbances of the neurophysiological sleep architecture in the course of the AD include deep sleep and paradoxical sleep deprivation. Among sleep disorders occurring in patients with AD, the most frequent disorders are sleep breathing disorders and restless legs syndrome. Sleep disorders may influence circadian fluctuations of the concentrations of amyloid-β in the interstitial brain fluid and in the cerebrovascular fluid related to the glymphatic brain system and production of the amyloid-β. There is accumulating evidence suggesting that disordered sleep contributes to cognitive decline and the development of AD pathology. In this mini-review, we highlight and discuss the association between sleep disorders and AD.
Highlights
Alzheimer’s disease (AD) is the most common cause of dementia, and its etiology is multifactorial (Chibber et al, 2016)
Based on the results obtained in the questionnaires, it has been found that sleep disorders occurred in 24.5% of patients with mild to moderate form of AD (Moran et al, 2005)
Sleep disorders in AD can be caused by breathing disorders during sleep and among them by repetitive obstructive sleep apnea (OSA)
Summary
Alzheimer’s disease (AD) is the most common cause of dementia, and its etiology is multifactorial (Chibber et al, 2016). A progressive study based on the Pittsburgh Sleep Quality Index and encompassing 1,664 persons at the age of 65 years without cognitive disorders during a 1-year observation found that extended sleep time (>9 h) among women and shortened sleep time (
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