Abstract
As women age and go through menopause, they suffer a higher incidence of sleep disorder, cardiovascular morbidity and mortality. In addition, evidences suggested that sleep disorder was an important pathological indicator for coronary heart disease. However, the relationship between different menopausal status, sleep disorder and cardiovascular diseases was unclear. Thus, we aim to assess the association between sleep disorder with arterial stiffness in females of 40–60 years free of cardiovascular diseases through self-administered Pittsburgh Sleep Quality Index (PSQI) and brachial-ankle pulse wave velocity (baPWV). Logistic regression revealed that sleep disorder (PSQI score ≥ 8) was an independent indicator for higher risk of elevated arterial stiffness (baPWV ≥ 1465.5 cm/s, upper tertile) beyond other established cardiovascular confounders in peri-postmenopause (OR 2.83, 95% confidence interval (CI) 2.00–4.00, p < 0.001), but not in premenopause (OR 1.67, 95% CI 0.71–3.90, p = 0.223). Collectively, it clearly indicates that sleep disorder in menopausal women is of prominent value to predict arterial stiffness.
Highlights
Menopause is a critical physiological stage of women’s life with various complaints and distresses due to the decline of ovarian hormones[1]
Lipid and glucose disorder, less employed, less income and more parity were observed in group of sleep disorder (PSQI ≥ 8)
After adjusting for established cardiovascular and demographic risk factors, we interestingly found that sleep disorder (PSQI ≥ 8) was associated with arterial stiffness in peri-postmenopausal women
Summary
Menopause is a critical physiological stage of women’s life with various complaints and distresses due to the decline of ovarian hormones[1]. The subjective sleep duration variablely associated with arterial stiffness, differing from studies[5, 6], and the evidence of the relationship between sleep duraion and cardiovascular risks for women was weaker and less conclusive than men[7]. Pulse wave velocity has been purported as a biomarker directly related to vessel stiffness that has the potential to provide siginals on early vascular aging and predict cardiovascular events It is most often determined through pulse wave velocity (PWV) between two arterial sites[9]. We aim to investigate this association in middle-aged Chinese women, and to identify the potential predicting value of sleep disorder for arterial stiffness in different menopausal status
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