Sleep apnoea syndrome in patients with chronic obstructive pulmonary disease and obesity – hypoxic load, comorbidities

Abstract

Abstract Introduction We analyse anthropometric, somnopolygraphic and comorbidities data in patients with OSA syndrome, OSA with COPD, and OSA with COPD and obesity. Material and method 2644 OSA patients, three groups: I – OSA (2112 pts., 79.9%); II – OSA and COPD (116 pts., 4.4%); III – OSA, COPD and obesity (416 pts., 15.7%). Results significantly older (p < 0.01, p = 001, p < 0.01); more men: 68.4% vs. 80.2% vs. 78.8%; smokers 59.4% vs. 70.7% vs. 74.3%; larger neck circumference: 42.74 ± 5.08 cm vs. 40.57 ± 3.97 cm vs. 45.90 ± 4.92 cm; higher BMI; lower O2 saturation: p < 0.01, p= 123, P < 0.01; higher desaturation index: 30.65 ± 26.96 vs. 18.94 ± 20.28 vs. 42.28 ± 29.02; lowest O2 saturation: (p < 0.01 0, p = 024, p< 0.01); higher AHI: p= 0.001, p < 0.01, p < 0.01; coronary artery disease: p < 0.01, p = 195, p < 0.01; heart failure: p < 0.01, p = 760, p < 0.01; arrhythmias: p < 0.01, p = 796, P < 0.01; stroke: unsignificant; diabetes mellitus: p = 0.252, p = 0.007, p = 0.794; systemic hypertension: p < 0.01, p = 0.786, p < 0.01. Conclusion COPD in OSA is more severe, with more diabetes and longer hypertension duration, but not significantly different for O2 saturation, CAD, heart failure, arrhythmia, stroke and systemic hypertension. Obesity adds to overlap OSA–COPD significant burden for all recorded data, with the exception of stroke and diabetes.