Abstract
Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.
Highlights
We devote 6–9 h of our life to sleep, a physiological state marked by muscle relaxation and reduced responsiveness to our surroundings
Sleep alternates between non-rapid-eye movement (NREM) sleep and rapid-eye movement (REM) sleep in a characteristic pattern known as the sleep cycle
Deep slow-wave sleep (SWS) predominates NREM sleep in the first half of the night, while the duration of REM sleep epochs progressively increases throughout the night
Summary
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Reviewed by: Ted Abel, University of Pennsylvania, USA Chiara Cirelli, University of Wisconsin-Madison, USA. Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. We discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function
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